Synthesis and Biological Evaluation of Thioglycosylated meso-Arylporphyrins

1999 ◽  
Vol 03 (01) ◽  
pp. 1-4 ◽  
Author(s):  
ISABELLE SYLVAIN ◽  
RACHIDA BENHADDOU ◽  
VINCENT CARRE ◽  
SYLVAIN COTTAZ ◽  
HUGUES DRIGUEZ ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Biological Evaluation ◽  
Malignant Cells ◽  
Yeast Saccharomyces Cerevisiae ◽  
New Class ◽  
Synthesis And Biological Evaluation

A new class of porphyrins bearing thioglycosyl groups is presented in order to improve targeting of malignant cells and resistance to glycosidases. These compounds were synthesized in four steps. They produced 1 O 2 and their photocytotoxicity against the yeast Saccharomyces cerevisiae was compared with the effect of haematoporphyrin.

Synthesis and biological evaluation of polyamine-porphyrin conjugates as potential agents in photodynamic therapy (PDT)

2002 ◽  
Vol 06 (02) ◽  
pp. 130-134 ◽  
Author(s):  
François Lamarche ◽  
Vincent Sol ◽  
Yi-Ming Huang ◽  
Robert Granet ◽  
Michel Guilloton ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Biological Evaluation ◽  
Myelogenous Leukemia ◽  
Leukemia Cells ◽  
Malignant Cells ◽  
Photofrin Ii ◽  
New Class ◽  
Human Chronic Myelogenous Leukemia ◽  
Chronic Myelogenous Leukemia Cells ◽  
Synthesis And Biological Evaluation

A new class of porphyrins bearing natural polyamines has been designed in order to target the photosensitizers towards malignant cells. We report here the synthesis of spermidine and spermine porphyrins. The photocytotoxicity of these compounds against K562 human chronic myelogenous leukemia cells has been evaluated and compared to Photofrin II®.

scholarly journals Synthesis and Biological Evaluation of 2-aroyl-4-phenyl-5- hydroxybenzofurans as a New Class of Antitubulin Agents

2008 ◽  
Vol 4 (6) ◽  
pp. 558-564 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Baraldi ◽  
Taradas Sarkar ◽  
Carlota Cara ◽  
Olga Lopez ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
New Class ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of nimesulide based new class of triazole derivatives as potential PDE4B inhibitors against cancer cells

2013 ◽  
Vol 23 (24) ◽  
pp. 6721-6727 ◽  
Author(s):  
Jyoti Mareddy ◽  
Suresh Babu Nallapati ◽  
Jayasree Anireddy ◽  
Yumnam Priyadarshini Devi ◽  
Lakshmi Narasu Mangamoori ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Biological Evaluation ◽  
Triazole Derivatives ◽  
New Class ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of benzothiazin-4-ones: a possible new class of acetylcholinesterase inhibitors

2018 ◽  
Vol 34 (1) ◽  
pp. 196-202 ◽  
Author(s):  
Gabriele A. Berwaldt ◽  
Daniela P. Gouvêa ◽  
Daniel S. da Silva ◽  
Adriana M. das Neves ◽  
Mayara S. P. Soares ◽  
...  
Keyword(s):  
Acetylcholinesterase Inhibitors ◽  
Biological Evaluation ◽  
New Class ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of 2-aminopyrimidinones and their 6-aza-analogs as a new class of CK2 inhibitors

2013 ◽  
Vol 29 (5) ◽  
pp. 639-646 ◽  
Author(s):  
Maksym O. Chekanov ◽  
Olga V. Ostrynska ◽  
Sergii S. Tarnavskyi ◽  
Anatoliy R. Synyugin ◽  
Nadiia V. Briukhovetska ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
New Class ◽  
Synthesis And Biological Evaluation ◽  
Ck2 Inhibitors

Synthesis and biological evaluation of arylidene analogues of Meldrum’s acid as a new class of antimalarial and antioxidant agents

2010 ◽  
Vol 18 (15) ◽  
pp. 5626-5633 ◽  
Author(s):  
Harmeet S. Sandhu ◽  
Sameer Sapra ◽  
Mukesh Gupta ◽  
Kunal Nepali ◽  
Raju Gautam ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
New Class ◽  
Antioxidant Agents ◽  
Synthesis And Biological Evaluation
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